Featured publications
Retrosplenial inputs drive visual representations in the medial entorhinal cortex
Dubanet O, Higley MJ (2024) Cell Reports
Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Benisty H, Barson D, Moberly AH, Lohani S, Tang L, Coifman RR, Crair MC, Mishne G, Cardin JA, Higley MJ (2024) Nature Neuroscience
Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression
Yao X, Chen R, Zhu J, Hou R, Xiang S, Jia T, Gu Y, Wang Z, Hu H, Chen H, Wang H, Feng J, Robbins TW, Wang Y, Higley MJ, Koleske AJ, Xiao X (2025) Molecular Psychiatry
Delayed integration of somatostatin interneurons into visual circuits
Wang A, Ferguson KA, Gupta J, Higley MJ, Cardin JA (2024) Nature Communications
Shared-AE: Automatic identication of shared subspaces in high-dimensional neural and behavioral activity
Yi D, Dong H, Higley MJ, Churchland A, Saxena S (2025) Int Conf Learn Represent
Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex
Dubanet O, Higley MJ (2024) Cell Reports
Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model
Bottom-Tanzer S, Corella S, Meyer J, Sommer M, Bolaños L, Murphy T, Quiñones S, Heiney S, Shtrahman M, Whalen M, Oren R, Higley MJ, Cardin JA, Noubary F, Armbruster M, Dulla C (2024) Cerebral Cortex
The Cousa objective: A long-working distance air objective for multiphoton imaging in vivo
Yu CH, Yu Y, Adsit LM, Chang JT, Barchini J, Moberly AH, Benisty H, Kim J, Young BK, Heng K, Farinella DM, Leikvoll A, Pavan R, Vistein R, Nanfito BR, Hildebrand DGC, Otero-Coronel S, Vaziri A, Goldberg JL, Ricci AJ, Fitzpatrick D, Cardin JA, Higley MJ, Smith GB, Kara P, Nielsen KJ, Smith IT, Smith SL (2024) Nature Methods
The Couse objective: A long working distance air objective for multiphoton imaging in vivo
Yu C, Yu Y, Adsit LM, Chang JT, Barchini J, Moberly AH, Benisty H, Kim J, Young BK, Heng K, Farinella DM, Leikvoll A, Pavan R, Vistein R, Nanfito BR, Hildebran DGC, Coronel S, Vaxiri A, Goldberg JL, Ricci AJ, Fitzpatrick D, Cardin JA, Higley MJ, SMith GB, Kara P, Nielsen KJ, Smith IT, Smith SL (2023) Nature Methods
Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Benisty H, Moberly AH, Lohani S, Barson D, Coifman RR, Mishne G, Cardin JA, Higley MJ (2024) Nature Neuroscience
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity
Lohani S*, Moberly AH, Benisty H, Landa B, Jing M, Li Y, Higley MJ*, Cardin JA*. (2022) Nature Neuroscience
Building bridges: Simultaneous multimodal imaging approaches for exploring the organization of brain networks
Lake EMR, Higley MJ (2022) Neurophotonics
Spatiotemporal dynamics in large-scale cortical networks
Cardin JA, Higley MJ (2022) Current Opinion in Neurobiology
Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI
Lake E, Ge X, Shen X, Herman P, Hyder F, Cardin JA, Higley MJ, Scheinost D, Papademetris X, Crair MC, Constable RT (2020) Nature Methods
NMDAR-dependent emergence of behavioral representation in primary visual cortex
Puscian A, Benisty H, Higley MJ (2020) Cell Reports
Diverse spatiotemporal scales of cholinergic signaling in the neocortex
Disney AA and Higley MJ (2020) Journal of Neuroscience
Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits
Barson D*, Hamodi AS*, Shen X, Lur G, Constable RT. Cardin JA, Crair MC, Higley MJ (2020) Nature Methods
Preserving the balance: Diverse forms of long-term GABAergic synaptic plasticity
Chiu CQ, Barberis A, Higley MJ (2018) Nature Reviews Neuroscience
Potassium channels contribute to activity-dependent scaling of dendritic inhibition
Chang JT, Higley MJ (2018) Physiological Reports
Millisecond precision temporal encoding of stimulus features during cortically generated gamma oscillations in the rat somatosensory cortex
Bessaih T, Higley MJ, Contreras D (2018) Journal of Physiology
Disruption of coordinated presynaptic and postsynaptic maturation underlies the defects in hippocampal synapse stability and plasticity in Abl2/Arg-deficient mice
Xiao X, Levy AD, Rosenberg BJ, Higley MJ, Koleske AJ (2016) Journal of Neuroscience
Visual deprivation during the critical period enhances layer 2/3 GABAergic inhibition in mouse V1
Kannan M, Gross GG, Arnold DB, Higley MJ (2016) Journal of Neuroscience
Projection-specific feature encoding by layer 5 cortical subnetworks
Lur G, Vinck MA, Tang L, Cardin JA, Higley MJ (2016) Cell Reports
Stress impairs prefrontal cortical function via D1 dopamine receptor interactions with hyperpolarization-activated cyclic nucleotide-gated channels
Gamo NJ, Lur G, Higley MJ, Wang M, Paspalas CD, Vijayraghavan S, Yang Y, Ramos BP, Peng K, Kata A, Boven L, Lin F, Roman L, Lee D, Arnsten AF (2015) Biological Psychiatry
Glutamate receptor modulation is restricted to synaptic microdomains
Lur G, Higley MJ (2015) Cell Reports
Neuromodulation by acetylcholine: examples from schizophrenia and depression
Higley MJ and Picciotto MR (2014) Current Opinion in Neurobiology
Localized GABAergic inhibition of dendritic calcium signalling
Higley MJ (2014) Nature Reviews Neuroscience
Wavelength-selective one- and two-photon uncaging of GABA
Amatrudo JM, Olson JP, Lur G, Chiu CQ, Higley MJ, Ellis-Davies GC (2014) ACS Chemical Neuroscience
Optically selective two-photon uncaging of glutamate at 900 nm
Olson JP, Kwon HB, Takasaki KT, Chiu CQ, Higley MJ, Sabatini BL, Ellis-Davies GC (2013) Journal of the American Chemical Society
Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2
Einstein EB, Asaka Y, Yeckel MF, Higley MJ, Picciotto MR (2013) European Journal of Neuroscience
Calcium signaling in dendritic spines
Higley MJ, Sabatini BL (2012) Cold Spring Harbor Perspectives in Biology
Determination of cortical circuit function using current source-density analysis in vivo
Higley MJ (2012) In: Neuronal Network Analysis, Tommaso Fellin and Michael Halassa, eds. Humana Press
Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors
Higley MJ, Sabatini BL (2010) Nature Neuroscience
Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration
Higley MJ*, Soler-Llavina GJ*, Sabatini BL (2009) Nature Neuroscience
Developmental presence and disappearance of postsynaptically silent synapses on dendritic spines of rat layer 2/3 pyramidal neurons
Busetto G, Higley MJ, Sabatini BL (2008) Journal of Physiology
Frequency adaptation modulates spatial integration of sensory responses in the rat whisker system
Higley MJ, Contreras D (2007) Journal of Neurophysiology
Cellular mechanisms of suppressive interactions between somatosensory responses in vivo
Higley MJ, Contreras D (2007) Journal of Neurophysiology
Balanced excitation and inhibition determine spike timing during frequency adaptation
Higley MJ, Contreras D (2006) Journal of Neuroscience
Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts
Traub RD, Contreras D, Cunningham MO, Murray H, LeBeau FE, Roopun A, Bibbig A, Wilent WB, Higley MJ, Whittington MA (2005) Journal of Neurophysiology
Integration of synaptic responses to neighboring whiskers in rat barrel cortex in vivo
Higley MJ, Contreras D (2005) Journal of Neurophysiology
Nonlinear integration of sensory responses in the rat barrel cortex: an intracellular study in vivo
Higley MJ, Contreras D (2003) Journal of Neuroscience
Recovery of associative function following early amygdala lesions in rats
Higley MJ, Hermer-Vazquez L, Levitsky DA, Strupp BJ (2001) Behavioral Neuroscience
